Protein Details: Transient receptor potential cation channel subfamily V member 2

Protein ID

ICDB_Pro_1700

Protein Name

Transient receptor potential cation channel subfamily V member 2

Gene Name

Trpv2 Sac2b Vrl1

Organism

Rattus norvegicus (Rat)

Length

761 amino acids

AlphaFoldDB

AF-Q9WUD2-F1-model_v4.pdb

Function

Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by growth factors, like IGF1, PDGF and morphogenetic neuropeptide/head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH (By similarity)

Sequence

MTSASSPPAFRLETSDGDEEGNAEVNKGKQEPPPMESPFQREDRNSSPQIKVNLNFIKRPPKNTSAPSQQEPDRFDRDRLFSVVSRGVPEELTGLLEYLRWNSKYLTDSAYTEGSTGKTCLMKAVLNLQDGVNACIMPLLQIDKDSGNPKLLVNAQCTDEFYQGHSALHIAIEKRSLQCVKLLVENGADVHLRACGRFFQKHQGTCFYFGELPLSLAACTKQWDVVTYLLENPHQPASLEATDSLGNTVLHALVMIADNSPENSALVIHMYDGLLQMGARLCPTVQLEEISNHQGLTPLKLAAKEGKIEIFRHILQREFSGPYQPLSRKFTEWCYGPVRVSLYDLSSVDSWEKNSVLEIIAFHCKSPNRHRMVVLEPLNKLLQEKWDRLVSRFFFNFACYLVYMFIFTVVAYHQPSLDQPAIPSSKATFGESMLLLGHILILLGGIYLLLGQLWYFWRRRLFIWISFMDSYFEILFLLQALLTVLSQVLRFMETEWYLPLLVLSLVLGWLNLLYYTRGFQHTGIYSVMIQKVILRDLLRFLLVYLVFLFGFAVALVSLSREARSPKAPEDNNSTVTEQPTVGQEEEPAPYRSILDASLELFKFTIGMGELAFQEQLRFRGVVLLLLLAYVLLTYVLLLNMLIALMSETVNHVADNSWSIWKLQKAISVLEMENGYWWCRRKKHREGRLLKVGTRGDGTPDERWCFRVEEVNWAAWEKTLPTLSEDPSGPGITGNKKNPTSKPGKNSASEEDHLPLQVLQSP

PDB Structures

2ETA 2ETB 2ETC 5HI9 6BO4 6BO5 6U84 6U86 6U88 6U8A 6WKN 7N0M 7N0N 7T37 7T38 7ZJD 7ZJE 7ZJG 7ZJH 7ZJI 8EKP 8EKQ 8EKR 8EKS 8SLX 8SLY

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

DOI ID

10.1038/18906; 10.1101/gr.2596504; 10.1046/j.1432-1033.2003.03811.x; 10.1002/jcb.10775; 10.1084/jem.20032082; 10.1038/ncomms1871; 10.1074/jbc.c600153200

RefSeq

NP_001257726.1; NP_001257727.1; NP_058903.2